What is CRMO?

Chronic Recurrent Multifocal Osteomyelitis, also known as Chronic Non-bacterial Osteomyelitis (CNO), is a rare, autoinflammatory bone disease of unknown etiology. It involves inflammation of one or more bones and can be chronic. In a properly functioning system, inflammation is a normal process and is the way the immune system protects us from infections and germs. However, in CRMO, there is no infection. The immune system wrongly attacks normal bone and causes inflammation.


CRMO is a diagnosis of exclusion and cannot be diagnosed until other diseases are ruled out. Malignancy and infectious osteomyelitis are differential diagnoses. Generally, many tests are required, such as blood tests, X-rays, bone scans, MRI, and often a bone biopsy. CRMO patients often go years without a proper diagnosis and treatment. For this reason and because the disease is not well known, most doctors have never even heard of CRMO, much less understand how to treat it.




The cause of CRMO is unknown. Genetic and environmental factors may play a role.


Find a doctor with experience treating patients with CRMO. CRMO is generally treated by a pediatric rheumatologist or adult rheumatologist. Ask your doctor for a referral. The goal is to find the right medications to stop inflammation and heal the affected bones. Some CRMO medication options are used in children with juvenile arthritis. Why do we treat CRMO?

  • Decrease pain
  • Reduce inflammation
  • Prevent bone damage and bone deformities (for example: fractures, leg length discrepancies, changes in spine curvature)
  • Help avoid growth problems


The prognosis will depend on each individual’s disease and response to treatment. The course can be different depending on the patient. For many patients with appropriate treatment, the disease may go into remission; for others, the disease may persist. Some may need to stay on medications for many years. Others may be able to stop the medications. This is why it is important to continue seeing your rheumatologist.

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2019 Webinars and Conferences

CORDS Workshop Webinar

Dr. Mark Lewis will present on how to prepare to meet with your health care provider and Jamie Husher will present on topics regarding how to access your medical records.

April 17, 2019 @12PM CT

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2019 National Juvenile Arthritis Conference

JA Conference – Houston
July 18 - 21, 2019
Hilton America’s Houston
Houston, Texas

JA Conference – Minneapolis
August 1 – 4, 2019

Hyatt Regency Minneapolis
Minneapolis, Minnesota

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Global Genes
Global Genes: RARE Patient Advocacy Summit

Two day conference to network with other rare diseases.


San Diego, California

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Rare Diseases and Orphan Products Breakthrough Summit

Summit attendees explored the new and innovative ways in which patients and caregivers are helping drive progress for the rare disease community.

October 21-22, 2019

Washington, D.C.

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